- API
Any substance that is represented for use in a drug and that, when used in the manufacturing, processing, or packaging ...
- Active Ingredient
Any component that is intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, ...
- CAS No.
Unique number assigned to a specific chemical (identified by its chemical name) by the American Chemical Society and ...
Silybin
Catalog No. | PI0124 |
---|---|
CAS No. | 22888-70-6 |
Molecular Formula | C25H22O10 |
Molecular Weight | 482.44 |
Purity | 20%-98% HPLC |
Package | 25 kg/drum |
Botanical Source | milk thistle seeds |
Appearance | Powder |
Shelf Life | 2 years |
Safety Tips of Silybin
Handling of silybin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.
Related Products
-
Catalog No.: HE0154
Specification: 1% 2% Silica AA or UV; 0.8% β-Sitosterol UV
Package: 25 kg/drum
Botanical Source: Nettle Herb
Related Applications
Liver Protection
The liver is the primary organ responsible for expelling and breaking down toxins entering the body. In particular, it produces bile, a detoxifying agent metabolically indispensable in breaking down fats from food. Many chemicals from nature could protect liver to help the process of detoxication.
Related Researches
- 1. Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: in vitro release kinetics and in vitro/in vivo correlations in beagle dogs.
Cao X, et al. Eur J Pharm Sci 2013 Jan 23;48(1-2):64-71.
- 2. Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy.
Xie Y, et al. Int J Pharm 2013 Jan 30;441(1-2):111-20.
- 3. Enhanced bioactivity of silybin B methylation products.
Sy-Cordero AA, et al. Bioorg Med Chem 2013 Feb 1;21(3):742-7.
- 4. Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Köck K, et al. Drug Metab Dispos 2013 May;41(5):958-65.
- 5. Biosafety and antioxidant effects of a beverage containing silymarin and arginine. A pilot, human intervention cross-over trial.
Valentová K, et al. Food Chem Toxicol 2013 Jun;56:178-83.
- 6. Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth.
Lee MH, et al. Cancer Prev Res (Phila) 2013 May;6(5):455-65.
- 7. HiFSA Fingerprinting Applied to Isomers with Near-Identical NMR Spectra: The Silybin/Isosilybin Case.
Napolitano JG, et al. J Org Chem 2013 Apr 5;78(7):2827-39.
- 8. Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver.
Purchartová K, et al. Appl Microbiol Biotechnol 2013 Mar 14.
- 9. The protective effect of silybin against lasalocid cytotoxic exposure on chicken and rat cell lines.
Radko L, et al. Biomed Res Int 2013;2013:783519.
- 10. Anti-cancer efficacy of silybin derivatives - a structure-activity relationship.
Agarwal C, et al. PLoS One 2013;8(3):e60074.